Examining the Link Between Obesity, Inflammation, and Response to Asthma Medications

details{'conditions': ['Asthma', 'Obesity'], 'countries': ['United States'], 'interventions': [{'name': 'Beclomethasone dipropionate HFA', 'type': 'DRUG', 'description': 'Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation'}, {'name': 'Tiotropium bromide', 'type': 'DRUG', 'description': 'Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation'}, {'name': 'Salmeterol xinafoate', 'type': 'DRUG', 'description': 'Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation'}], 'sponsors': [{'name': 'National Heart, Lung, and Blood Institute (NHLBI)', 'role': 'collaborator', 'agency_class': 'NIH'}, {'name': 'National Jewish Health', 'role': 'lead', 'agency_class': 'OTHER'}], 'facilities': [{'zip': '92093', 'city': 'San Diego', 'name': 'University of California, San Diego', 'state': 'California', 'country': 'United States'}, {'zip': '94143', 'city': 'San Francisco', 'name': 'University of California, San Francisco', 'state': 'California', 'country': 'United States'}, {'zip': '80206', 'city': 'Denver', 'name': 'National Jewish Medical & Research Center', 'state': 'Colorado', 'country': 'United States'}, {'zip': '02115', 'city': 'Boston', 'name': "Brigham & Women's Hospital", 'state': 'Massachusetts', 'country': 'United States'}, {'zip': '63130', 'city': 'St Louis', 'name': 'Washington University', 'state': 'Missouri', 'country': 'United States'}, {'zip': '10032', 'city': 'New York', 'name': 'Columbia University Medical Center', 'state': 'New York', 'country': 'United States'}, {'zip': '27710', 'city': 'Durham', 'name': 'Duke University Medical Center', 'state': 'North Carolina', 'country': 'United States'}, {'zip': '27157', 'city': 'Winston-Salem', 'name': 'Wake Forest University Health Sciences', 'state': 'North Carolina', 'country': 'United States'}, {'zip': '77555', 'city': 'Galveston', 'name': 'University of Texas Medical Branch', 'state': 'Texas', 'country': 'United States'}, {'zip': '53706', 'city': 'Madison', 'name': 'University of Wisconsin', 'state': 'Wisconsin', 'country': 'United States'}], 'outcomes': [], 'brief_summary': 'Asthma is a common, long-term disease that is caused by inflammation of the airways. Inflammation also plays a role in obesity and may affect the way a person responds to asthma medication. This study will examine the relationship between obesity and inflammation and the effect they have on response to corticosteroid asthma medications.', 'study_type': 'OBSERVATIONAL', 'source_organization': 'National Jewish Health', 'results_first_posted_date': None, 'has_results_basis': 'results_first_posted_date'}→{'conditions': ['Asthma', 'Obesity'], 'countries': ['United States'], 'interventions': [{'name': 'Beclomethasone dipropionate HFA', 'type': 'DRUG', 'description': 'Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation', 'other_names': ['QVAR® 40 mcg or QVAR® 80 mcg'], 'design_groups': [{'id': 421414201, 'type': None, 'title': 'BASALT', 'description': 'Participants in the ACRN BASALT study'}]}, {'name': 'Tiotropium bromide', 'type': 'DRUG', 'description': 'Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation', 'other_names': ['Spiriva®'], 'design_groups': [{'id': 421414202, 'type': None, 'title': 'TALC', 'description': 'Participants in the ACRN TALC study'}]}, {'name': 'Salmeterol xinafoate', 'type': 'DRUG', 'description': 'Participants will receive the BASALT and TALC study drugs as determined in those protocols NCT00495157, NCT00565266. This study is ancillary to those trials and observational only and does not have any control over study drug allocation', 'other_names': ['Serevent®'], 'design_groups': [{'id': 421414202, 'type': None, 'title': 'TALC', 'description': 'Participants in the ACRN TALC study'}]}], 'composition_semantics': 'study_intervention_labels_not_product_formula', 'sponsors': [{'name': 'National Heart, Lung, and Blood Institute (NHLBI)', 'role': 'collaborator', 'agency_class': 'NIH'}, {'name': 'National Jewish Health', 'role': 'lead', 'agency_class': 'OTHER'}], 'facilities': [{'zip': '92093', 'city': 'San Diego', 'name': 'University of California, San Diego', 'state': 'California', 'country': 'United States'}, {'zip': '94143', 'city': 'San Francisco', 'name': 'University of California, San Francisco', 'state': 'California', 'country': 'United States'}, {'zip': '80206', 'city': 'Denver', 'name': 'National Jewish Medical & Research Center', 'state': 'Colorado', 'country': 'United States'}, {'zip': '02115', 'city': 'Boston', 'name': "Brigham & Women's Hospital", 'state': 'Massachusetts', 'country': 'United States'}, {'zip': '63130', 'city': 'St Louis', 'name': 'Washington University', 'state': 'Missouri', 'country': 'United States'}, {'zip': '10032', 'city': 'New York', 'name': 'Columbia University Medical Center', 'state': 'New York', 'country': 'United States'}, {'zip': '27710', 'city': 'Durham', 'name': 'Duke University Medical Center', 'state': 'North Carolina', 'country': 'United States'}, {'zip': '27157', 'city': 'Winston-Salem', 'name': 'Wake Forest University Health Sciences', 'state': 'North Carolina', 'country': 'United States'}, {'zip': '77555', 'city': 'Galveston', 'name': 'University of Texas Medical Branch', 'state': 'Texas', 'country': 'United States'}, {'zip': '53706', 'city': 'Madison', 'name': 'University of Wisconsin', 'state': 'Wisconsin', 'country': 'United States'}], 'outcomes': [], 'brief_summary': 'Asthma is a common, long-term disease that is caused by inflammation of the airways. Inflammation also plays a role in obesity and may affect the way a person responds to asthma medication. This study will examine the relationship between obesity and inflammation and the effect they have on response to corticosteroid asthma medications.', 'study_type': 'OBSERVATIONAL', 'source_organization': 'National Jewish Health', 'results_first_posted_date': None, 'has_results_basis': 'results_first_posted_date', 'start_date_type': 'ACTUAL', 'start_month_year': '2007-10', 'start_date_precision': 'month', 'completion_date_type': 'ACTUAL', 'completion_month_year': '2011-02', 'completion_date_precision': 'month', 'primary_completion_date': '2011-02-28', 'primary_completion_month_year': '2011-02', 'primary_completion_date_precision': 'month', 'primary_completion_date_type': 'ACTUAL', 'intervention_component_groups': [['unmapped:beclomethasone-dipropionate-hfa'], ['unmapped:tiotropium-bromide'], ['salmeterol']], 'intervention_normalization': [{'name': 'Beclomethasone dipropionate HFA', 'selected_label': 'Beclomethasone dipropionate HFA', 'selection_basis': 'primary_label', 'role': 'study_intervention', 'components': ['unmapped:beclomethasone-dipropionate-hfa'], 'unverified_label_components': ['unmapped:beclomethasone-dipropionate-hfa'], 'items': [{'original': 'Beclomethasone dipropionate HFA', 'component': 'unmapped:beclomethasone-dipropionate-hfa', 'status': 'unresolved', 'method': 'no_verified_mapping'}], 'excluded_accessory_parts': [], 'verified_other_name_component_sets': []}, {'name': 'Tiotropium bromide', 'selected_label': 'Tiotropium bromide', 'selection_basis': 'primary_label', 'role': 'study_intervention', 'components': ['unmapped:tiotropium-bromide'], 'unverified_label_components': ['unmapped:tiotropium-bromide'], 'items': [{'original': 'Tiotropium bromide', 'component': 'unmapped:tiotropium-bromide', 'status': 'unresolved', 'method': 'no_verified_mapping'}], 'excluded_accessory_parts': [], 'verified_other_name_component_sets': []}, {'name': 'Salmeterol xinafoate', 'selected_label': 'Salmeterol xinafoate', 'selection_basis': 'primary_label', 'role': 'study_intervention', 'components': ['salmeterol'], 'unverified_label_components': [], 'items': [{'original': 'Salmeterol xinafoate', 'component': 'salmeterol', 'status': 'resolved', 'method': 'versioned_lexicon'}], 'excluded_accessory_parts': [], 'verified_other_name_component_sets': []}]}